The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 15, 2024

Filed:

Nov. 01, 2018
Applicants:

Queen's University AT Kingston, Kingston, CA;

Kingston Health Sciences Centre, Kingston, CA;

Emory University, Atlanta, GA (US);

Georgia Tech Research Corporation, Atlanta, GA (US);

Inventors:

Philip Zakas, Cambridge, MA (US);

David Lillicrap, Kingston, CA;

Christopher Doering, Atlanta, GA (US);

Eric Gaucher, Atlanta, GA (US);

Caelan Radford, Seattle, WA (US);

Harold Trent Spencer, Atlanta, GA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/745 (2006.01); A61K 38/36 (2006.01); A61P 7/04 (2006.01); C07K 14/755 (2006.01); C12N 15/86 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61P 7/04 (2018.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2740/10043 (2013.01);
Abstract

A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.


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