The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
May. 21, 2024
Shanghai Jiaotong University, Shanghai, CN;
Sph No.1 Biochemical & Pharmaceutical Co., Ltd., Shanghai, CN;
Wanbin Zhang, Shanghai, CN;
Yaohua Zhang, Shanghai, CN;
Feng Gao, Shanghai, CN;
Wei Yu, Shanghai, CN;
Jing Li, Shanghai, CN;
Ximing Jiang, Shanghai, CN;
Zhenfeng Zhang, Shanghai, CN;
Liang Wu, Shanghai, CN;
Yuanlin Wang, Shanghai, CN;
Yujia Fu, Shanghai, CN;
SHANGHAI JIAOTONG UNIVERSITY, Shanghai, CN;
SPH NO.1 BIOCHEMICAL & PHARMACEUTICAL CO., LTD., Shanghai, CN;
Abstract
A low-temperature continuous-flow preparation method of bedaquiline includes the following steps. (a) A first feed liquid and a second feed liquid are subjected to a first continuous flow reaction for 30-600 seconds to obtain a first reaction mixture. (b) The first reaction mixture and a third feed liquid are subjected to a second continuous flow reaction for 30-600 seconds to obtain a second reaction mixture. (c) The second reaction mixture was quenched to afford bedaquiline.