The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Dec. 12, 2019
Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang, CN;
Shanghai Syncores Technologies Inc. Ltd., Shanghai, CN;
Haisheng Fan, Shanghai, CN;
Yipeng Zhan, Shanghai, CN;
Kai Yin, Shanghai, CN;
Xiang Ji, Shanghai, CN;
Fenghao Liu, Shanghai, CN;
Kaiqiang Shi, Shanghai, CN;
Xiaowen Guo, Shanghai, CN;
Luning Huang, Shanghai, CN;
Anping Tao, Shanghai, CN;
Jianguo An, Shanghai, CN;
Hong Gu, Shanghai, CN;
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, Zhejiang, CN;
SHANGHAI SYNCORES TECHNOLOGIES INC. LTD., Shanghai, CN;
Abstract
The present application relates to a method (I) for preparing a brivaracetam intermediate, comprising the steps of dissolving the compound represented by B-P and 1S,2S-diphenylethylenediamine in a solvent for resolution, crystallizing, filtering, and recrystallizing to obtain the compound represented by B-Q, which is then converted to the brivaracetam intermediate represented by B-R. This method can effectively resolve the compound represented by B-P. The present application also provides a method for preparing brivaracetam using the compound represented by B-R. The method can separate the effective components only through simple steps such as extraction, washing, drying, and concentration without requiring use of chiral chromatography column to separate isomers in the preparation process, and thus the separation process is simple, greatly reducing the production cost of brivaracetam.