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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12115230 B1

PDFFull Text
Date of Patent:
Oct. 15, 2024

Filed:

Apr. 09, 2021

Base editing of angptl3 and methods of using same for treatment of disease

Applicant:

Verve Therapautics, Inc., Boston, MA (US);

Inventors:

Alexandra Chadwick, Somerville, MA (US);

Kallanthottathil G. Rajeev, Wayland, MA (US);

Ellen Rohde, Ashland, MA (US);

Christopher Cheng, North Reading, MA (US);

Caroline Reiss, Somerville, MA (US);

Assignee:

VERVE THERAPEUTICS, INC., Boston, MA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Ekaterina Poliakova-Georgantas

Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 38/46 (2006.01); A61K 48/00 (2006.01); C07K 14/515 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 9/127 (2013.01); A61K 31/7105 (2013.01); A61K 38/465 (2013.01); C07K 14/515 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/113 (2013.01); C12N 15/907 (2013.01); C07K 2319/09 (2013.01); C07K 2319/80 (2013.01); C12N 2310/20 (2017.05); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/331 (2013.01); C12N 2310/335 (2013.01); C12N 2310/344 (2013.01); C12N 2310/3521 (2013.01); C12N 2800/80 (2013.01);
Abstract

Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.

Find Patent Forward Citations

Chadwick, Alexandra. (2024). Base editing of angptl3 and methods of using same for treatment of disease (U.S. Patent No. 12115230). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12115230

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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