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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12115212 B1

PDFFull Text
Date of Patent:
Oct. 15, 2024

Filed:

Aug. 30, 2019

Methods of decreasing amyloid beta (aβ) plaque deposition and hyperphosphorylated tau plaque deposition in alzheimer's disease using a cystatin c fusion protein

Applicant:

L & J Bio Co., Ltd., Seoul, KR;

Inventors:

Sookhee Bang, Fairfax, VA (US);

Jeong Kuen Song, Gaithersburg, MD (US);

Seung-Wook Shin, Clarksburg, MD (US);

Kwan Hee Lee, Las Vegas, NV (US);

Ho June Lee, Potomac, MD (US);

Assignee:

L & J Bio Co., Ltd., Seoul, KR;

Attorneys:

FisherBroyles, LLP

Joseph Hyosuk Kim

Primary Examiner:

Chang-Yu Wang

Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01); A61K 38/38 (2006.01); A61K 38/46 (2006.01); A61K 38/50 (2006.01); A61K 38/57 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61K 38/57 (2013.01); A61K 38/1709 (2013.01); A61K 38/1774 (2013.01); A61K 38/179 (2013.01); A61K 38/385 (2013.01); A61K 38/465 (2013.01); A61K 38/50 (2013.01); A61P 25/28 (2018.01);
Abstract

The present application discloses a method for treating a protein deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion polypeptide comprising the first protein, wherein the fusion polypeptide comprises: (a) the first protein; (b) a second protein that provides extended circulation-lifetime in vivo and (c) blood brain barrier crossing facilitating peptide; wherein the fusion polypeptide crosses the blood brain barrier (BBB).

Find Patent Forward Citations

Bang, Sookhee. (2024). Methods of decreasing amyloid beta (aβ) plaque deposition and hyperphosphorylated tau plaque deposition in alzheimer's disease using a cystatin c fusion protein (U.S. Patent No. 12115212). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12115212

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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