The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 15, 2024
Filed:
Jul. 21, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Christine E. Brown, Duarte, CA (US);
Stephen J. Forman, Duarte, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 39/001112 (2018.08); A61K 39/001119 (2018.08); A61P 35/00 (2018.01); C07K 16/2803 (2013.01); C07K 16/2866 (2013.01); C12N 5/0636 (2013.01); C12N 15/86 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 2317/622 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/2315 (2013.01); C12N 2510/00 (2013.01);
Abstract
Methods for preparing T cell populations useful for a variety of purposes requiring a highly active, long-lived T cell population. The T cell populations are enriched for: naive T cells (TN), memory stem cells (TSCM) and central memory T cells (TCM). These cell populations can be derived from peripheral blood mononuclear cells (PBMC) by both: 1) depleting unwanted cell populations such as CD14 expressing myeloid cells and CD25 expressing cells; and 2) enriching for CD62L expressing memory and naive T cells.