Endoluminal nerve modulation device and methods for using thereof

Abstract

The invention provides for a device () for use in electrical nerve modulation in a subject, characterized in that it comprises a rotational and linear actuator (); a tubular element () having a proximal end connected to the actuator () and a distal end; a flexible shaft () coaxially disposed within the tubular element (), comprising a proximal end operably connected to the actuator () and a distal end, and adapted to be slid along the tubular element (); a conformable support () comprising a proximal end operably connected to the tubular element's () distal end, and a distal end operably connected to the flexible shaft's () distal end, having a portion of its length helically wrapped about a distal portion of the flexible shaft () so to define a pitch () and a radius (); and a plurality of electrodes () operably disposed along the helically configured portion of the conformable support (), and electrically connectable to a generator (), adapted to contact the endoluminal surface of a blood vessel of the subject and deliver electrical energy; wherein the pitch (), radius () or both of the helically configured portion of the conformable support () can be modified via actuator's () driven extension, retraction and/or rotation of the flexible shaft ().