The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2024
Filed:
Mar. 02, 2022
Applicant:
Takeda Pharmaceutical Company Limited, Osaka, JP;
Inventors:
Andrew Nixon, Hanover, MA (US);
Jon A. Kenniston, Hingham, MA (US);
Stephen R. Comeau, Avon, NY (US);
Assignee:
Takeda Pharmaceutical Company Limited, Osaka, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); C07K 2317/34 (2013.01); C07K 2317/565 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract
Disclosed herein are antibodies capable of binding to plasma kallikrein and inhibit its activity. Such antibodies interact with one or more critical residues in the catalytic domain of the plasma kallikrein. The antibodies may also contain specific heavy chain complementarity determining region 3 (CDRs) motifs and optionally specific residues at certain positions within both the heavy chain variable region and the light chain variable region.