The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2024
Filed:
Oct. 13, 2021
Applicant:
Yale University, New Haven, CT (US);
Inventors:
William L. Jorgensen, Deep River, CT (US);
Joseph Schlessinger, Woodbridge, CT (US);
Assignee:
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 249/14 (2006.01); A61K 31/4196 (2006.01); A61K 31/4245 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01);
U.S. Cl.
CPC ...
C07D 249/14 (2013.01); A61K 31/4196 (2013.01); A61K 31/4245 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01);
Abstract
The compounds of Formula I described herein regulate activity of JAK2 by specifically binding to the JAK2 pseudokinase domain, JH2, and are useful as therapeutic agents in the treatment or amelioration of myeloproliferative disorders. Also provided herein are methods of treating myeloproliferative disorders, and methods of making compounds of Formula I.