Micro-fluidic device for concentration of particles via centrifugal force, and corresponding centrifugation and/or detection device

Abstract

A microfluidic device for concentrating particles contained in a fluid sample (FS) comprises a substrate () configured for being set in rotation about a centre of rotation (), the substrate () having a surface () defined in which is at least one microfluidic arrangement () that extends substantially according to a plane identified by the substrate (). The at least one microfluidic arrangement () comprises at least one microchannel () having a first end () and a second end (), wherein: —the at least one microchannel () comprises, in a region thereof intermediate between its first end () and its second end (), at least one accumulation area () that is at a first distance (R) in a radial direction (R) from the centre of rotation () of the substrate (); —the first end () and the second end () of the at least one microchannel () are at second distances (R) in a radial direction (R) from the centre of rotation () of the substrate (); and —the first distance (R) in a radial direction (R) is greater than the second distances (R) in a radial direction (R), in such a way that particles (P) possibly contained in a volume of fluid of the fluid sample (FS) that penetrates into the at least one microchannel () tend to concentrate in the at least one accumulation area () as a result of the centrifugal force caused by a rotation of the substrate () about the centre of rotation ().