The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 08, 2024

Filed:

Jul. 28, 2017
Applicant:

Academia Sinica, Taipei, TW;

Inventors:

Che-Ming Jack Hu, Taipei, TW;

Hui-Wen Chen, Taipei, TW;

Yuan-I Chen, Taipei, TW;

Chen-Ying Chien, Taichung, TW;

Jung-Chen Lin, New Taipei, TW;

Assignee:

Academia Sinica, Taipei, TW;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); C12N 5/078 (2010.01); G01N 33/50 (2006.01); G01N 33/543 (2006.01); G01N 33/556 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 9/1275 (2013.01); A61K 9/1277 (2013.01); C12N 5/0634 (2013.01); G01N 33/5008 (2013.01); G01N 33/5432 (2013.01); G01N 33/556 (2013.01); G01N 2500/02 (2013.01); G01N 2500/10 (2013.01);
Abstract

A method of generating an internally fixed lipid vesicle, comprising: providing a precursor lipid vesicle that contains an aqueous interior enclosed by a lipid membrane, wherein the lipid membrane of the precursor lipid vesicle is non-permeable to a crosslinker; permeabilizing the lipid membrane transiently to generate a permeable vesicle; contacting the permeable vesicle with an inactive activatable crosslinker, whereby the inactive activatable crosslinker enters the permeable vesicle; allowing the permeable vesicle to return to a non-permeable vesicle; removing any extravesicular crosslinker; and activating the inactive activatable crosslinker to allow crosslinking to occur inside the non-permeable vesicle, whereby an internally fixed lipid vesicle is generated.


Find Patent Forward Citations

Hu, Che-Ming. (2024). Internally fixed lipid vesicle (U.S. Patent No. 12109309). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12109309

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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