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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12109304 B1

PDFFull Text
Date of Patent:
Oct. 08, 2024

Filed:

Nov. 28, 2023

Oral patch for treating mouth ulcers

Applicant:

Xiamen Lp Pharmaceutical Co., Ltd., Xiamen, CN;

Inventors:

Haijian Zhu, Xiamen, CN;

Rongbin Ling, Xiamen, CN;

Avinash Singh, Xiamen, CN;

Liyan Xie, Xiamen, CN;

Xiaojin Xiao, Xiamen, CN;

Assignee:

XIAMEN LP PHARMACEUTICAL CO., LTD., Xiamen, CN;

Attorneys:

Perkins Coie LLP

Viola T. Kung

Primary Examiner:

Sin J Lee

Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 9/70 (2006.01); A61K 31/245 (2006.01); A61K 31/573 (2006.01); A61K 47/08 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2017.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61K 47/42 (2017.01); A61K 47/44 (2017.01); A61P 1/04 (2006.01); A61P 17/02 (2006.01);
U.S. Cl.
CPC ...
A61K 9/006 (2013.01); A61K 9/7046 (2013.01); A61K 9/7053 (2013.01); A61K 9/7061 (2013.01); A61K 9/7069 (2013.01); A61K 31/245 (2013.01); A61K 31/573 (2013.01); A61K 47/08 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61K 47/42 (2013.01); A61K 47/44 (2013.01); A61P 1/04 (2018.01); A61P 17/02 (2018.01);
Abstract

The present invention provides an oral patch for localized treatment of mouth ulcers containing combination of tetracaine and triamcinolone as active drugs. The patch is a bilayer structure containing a drug layer with amorphous tetracaine hydrochloride and amorphous triamcinolone acetonide and a water-soluble backing layer without a drug. The oral patch with combination of drugs has improved efficacy over each individual drug. The drug layer comprises 3-20% by weight of amorphous tetracaine hydrochloride, or a pharmaceutical acceptable salt thereof, 0.1-2.0% by weight of amorphous triamcinolone acetonide or a pharmaceutical acceptable salt thereof, 20-95% by weight of a first film-forming material, 1-12% by weight of an adhesive, 1-20% by weight of one or more cooling agent, and optionally 1-12% by weight of a plasticizer. The backing layer comprises 70-95% by weight of one or more film-forming agents, 2-10% by weight of a plasticizer and optionally 1-8% by weight of a flavoring agent.

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