The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 08, 2024
Filed:
Jan. 22, 2021
Applicant:
Northwestern University, Evanston, IL (US);
Inventors:
Jing Jin, Hinsdale, IL (US);
Xinfang Xie, Evanston, IL (US);
Assignee:
Northwestern University, Evanston, IL (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2024.01); C07K 14/36 (2006.01); C07K 16/00 (2006.01); C07K 19/00 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
A01K 67/027 (2013.01); C07K 14/36 (2013.01); C07K 16/00 (2013.01); C07K 19/00 (2013.01); G01N 33/5088 (2013.01); A01K 2207/10 (2013.01); C07K 2317/41 (2013.01); C07K 2317/53 (2013.01);
Abstract
Recombinant poly-IgA oligomers that form high-order oligomers resembling poly-IgA of IgA nephropathy are provided. Injection of recombinant IgA oligomers in an animal model produces prominent renal glomerular mesangial deposition of recombinant poly IgA oligomer, as in IgA nephropathy patients. Thus, producing a model of IgAN pathology that is able to provide screening and evaluation of therapeutic drugs and diagnostic tests.