The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2024
Filed:
Apr. 08, 2022
Applicant:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Inventors:
Meritxell Galindo Casas, Graz, AT;
Thomas John Van Blarcom, Oakland, CA (US);
Assignee:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/64 (2006.01); A61K 31/7088 (2006.01); A61K 35/17 (2015.01); A61K 38/48 (2006.01); A61K 38/52 (2006.01); C12N 5/0783 (2010.01); C12N 9/90 (2006.01); C12N 11/18 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6472 (2013.01); A61K 31/7088 (2013.01); A61K 35/17 (2013.01); A61K 38/4873 (2013.01); A61K 38/52 (2013.01); C12N 5/0636 (2013.01); C12N 9/90 (2013.01); C12N 11/18 (2013.01); C12Y 304/22062 (2013.01); C12Y 502/01008 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01); C12N 2501/734 (2013.01); C12N 2510/00 (2013.01); C12N 2740/16043 (2013.01);
Abstract
Provided herein are modified caspase-9 polypeptides, and chimeric caspase-9 proteins containing the modified caspase-9 polypeptides. The disclosure further provides polynucleotides encoding these proteins, engineered host cells containing these polynucleotides and proteins, including host cells that co-express a chimeric antigen receptor, and methods of making and using the same.