The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 01, 2024

Filed:

Mar. 18, 2019
Applicants:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

Aum Lifetech, Inc, Philadelphia, PA (US);

Inventors:

Tejvir S. Khurana, Narnerth, PA (US);

Manoj Kumar Mishra, Philadelphia, PA (US);

Veenu Aishwarya, Philadelphia, PA (US);

Assignees:

The Trustees of the University of Pennsylvania, Philadelphia, PA (US);

AUM LifeTech, Inc, Philadelphia, PA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61P 21/00 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61P 21/00 (2018.01);
Abstract

The invention relates to compositions and methods for enhancing or upregulating utrophin protein production and methods for treating myopathies, such as Duchenne Muscular Dystrophy (DMD). Specifically, the invention relates to compositions, such as oligonucleotides, and methods for enhancing or upregulating utrophin in a subject by blocking binding of let-7c miRNA to the utrophin mRNA 3 untranslated region (UTR).


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