The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 01, 2024

Filed:

Sep. 09, 2021
Applicant:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Inventors:

Christian Klein, Bonstetten, CH;

Ekkehard Moessner, Kreuzlingen, CH;

Ralf Hosse, Cham, CH;

Peter Bruenker, Hittnau, CH;

Pablo Umana, Wollerau, CH;

Christiane Neumann, Niederweningen, CH;

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); A61K 39/00 (2006.01); A61K 39/385 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C12N 15/73 (2006.01);
U.S. Cl.
CPC ...
C07K 16/464 (2013.01); A61K 39/001102 (2018.08); A61K 39/00117 (2018.08); A61K 39/385 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/2878 (2013.01); C07K 16/30 (2013.01); C07K 16/468 (2013.01); C12N 15/73 (2013.01); A61K 2039/5158 (2013.01); C07K 16/46 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/41 (2013.01); C07K 2317/515 (2013.01); C07K 2317/71 (2013.01); C07K 2317/73 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01);
Abstract

The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells comprising a common light chain. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.


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