The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2024
Filed:
Oct. 05, 2022
Immunocore Limited, Abingdon, GB;
Marcin Dembek, Abingdon, GB;
Luis Filipe Da Silva Godinho, Abingdon, GB;
Praveen Singh, Abingdon, GB;
Emma Elizabeth Baston, Abingdon, GB;
Andrew Creese, Abingdon, GB;
Thomas Minshull, Abingdon, GB;
Pranav Bheamadu, Abingdon, GB;
IMMUNOCORE LIMITED, Abingdon, GB;
Abstract
Specific binding molecules, including T cell receptors (TCRs), which bind the HLA-A*02 restricted peptide SLYNTVATL (SEQ ID NO: 1) derived from the HIV Gag gene product, p17 are presented. TCRs of the present invention comprise non-natural mutations within the alpha and/or beta variable domains relative to a native TCR. The specific binding molecules of the invention have improved stability and/or yield and yet unexpectedly retain the advantageous properties of the specific binding molecules from which they are derived. Such specific binding molecules are particularly useful in the development of soluble immunotherapeutic reagents for the treatment of HIV infected individuals.