The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 2024
Filed:
Apr. 17, 2019
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventors:
Drew Adams, Cleveland, OH (US);
Dharmaraja Allimuthu, Cleveland, OH (US);
Zita Hubler, Cleveland, OH (US);
Assignee:
Case Western Reserve University, Cleveland, OH (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/575 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/661 (2006.01); A61P 25/28 (2006.01); C07J 9/00 (2006.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
A61K 31/575 (2013.01); A61K 31/57 (2013.01); A61K 31/573 (2013.01); A61K 31/661 (2013.01); A61P 25/28 (2018.01); C07J 9/00 (2013.01); C12N 5/0622 (2013.01); C12N 2501/999 (2013.01);
Abstract
A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of 8,9-unsaturated sterols in the OPCs, the agent comprising a compound having the formula (I): wherein variables Y, Rand Rare as defined herein.