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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12099056 B1

PDFFull Text
Date of Patent:
Sep. 24, 2024

Filed:

Dec. 17, 2021

Reagents, methods, and systems for detecting therapeutic agents to monitor adherence to nucleoside reverse transcriptase inhibitor metabolites

Applicant:

Orasure Technologies, Inc., Bethlehem, PA (US);

Inventors:

Giffin Daughtridge, Cambridge, MA (US);

Keith Kardos, Bethlehem, PA (US);

Sharanappa Basappa Rajur, Andover, MA (US);

Kim Hwa-Ok, Lexington, MA (US);

Asharani Dhondiram Kadam, Andover, MA (US);

Assignee:

ORASURE TECHNOLOGIES, INC., Bethlehem, PA (US);

Attorneys:

RAPHAEL BELLUM PLLC

Stephen C. Bellum

Primary Examiner:

Galina M Yakovleva

Int. Cl.
CPC ...
G01N 33/53 (2006.01); C07K 16/44 (2006.01); G01N 33/543 (2006.01); G01N 33/577 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5308 (2013.01); C07K 16/44 (2013.01); G01N 33/54388 (2021.08); G01N 33/577 (2013.01); C07K 2317/565 (2013.01); G01N 2430/60 (2013.01);
Abstract

The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and uses thereof in monitoring adherence to pre-exposure prophylaxis. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for antibody-based methods, such as a lateral flow immunoassay and other point of care devices.

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Daughtridge, Giffin. (2024). Reagents, methods, and systems for detecting therapeutic agents to monitor adherence to nucleoside reverse transcriptase inhibitor metabolites (U.S. Patent No. 12099056). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12099056

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