The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Jun. 05, 2020
Applicant:
Amyris, Inc., Emeryville, CA (US);
Inventors:
Penelope R. Chua, Emeryville, CA (US);
Joshua Adam Lerman, Emeryville, CA (US);
Thomas Jon Scherbart, Emeryville, CA (US);
Chandresh Thakker, Emeryville, CA (US);
Annie Ening Tsong, Emeryville, CA (US);
Hanxiao Jiang, Emeryville, CA (US);
Assignee:
Amyris Inc., Emeryville, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/14 (2006.01); C12N 1/18 (2006.01); C12N 9/02 (2006.01); C12N 9/14 (2006.01); C12N 15/81 (2006.01); C12P 5/00 (2006.01);
U.S. Cl.
CPC ...
C12P 5/007 (2013.01); C12N 1/18 (2013.01); C12N 9/0036 (2013.01); C12N 9/14 (2013.01); C12N 15/81 (2013.01);
Abstract
Provided herein are compositions and methods for uncoupling the yield and productivity of an isoprenoid compound produced in a host cell. In some embodiments, the yield and productivity are uncoupled by genetically modifying the host cell to reduce flux through the citric acid cycle (TCA). In other embodiments, the yield and productivity are uncoupled by reducing the levels of ATP in the host cell.