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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12098407 B1

PDFFull Text
Date of Patent:
Sep. 24, 2024

Filed:

Jun. 05, 2020

Methods for decoupling yield and productivity of a non-catabolic compound produced by a host cell

Applicant:

Amyris, Inc., Emeryville, CA (US);

Inventors:

Penelope R. Chua, Emeryville, CA (US);

Joshua Adam Lerman, Emeryville, CA (US);

Thomas Jon Scherbart, Emeryville, CA (US);

Chandresh Thakker, Emeryville, CA (US);

Annie Ening Tsong, Emeryville, CA (US);

Hanxiao Jiang, Emeryville, CA (US);

Assignee:

Amyris Inc., Emeryville, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Yong D Pak

Int. Cl.
CPC ...
C12N 1/14 (2006.01); C12N 1/18 (2006.01); C12N 9/02 (2006.01); C12N 9/14 (2006.01); C12N 15/81 (2006.01); C12P 5/00 (2006.01);
U.S. Cl.
CPC ...
C12P 5/007 (2013.01); C12N 1/18 (2013.01); C12N 9/0036 (2013.01); C12N 9/14 (2013.01); C12N 15/81 (2013.01);
Abstract

Provided herein are compositions and methods for uncoupling the yield and productivity of an isoprenoid compound produced in a host cell. In some embodiments, the yield and productivity are uncoupled by genetically modifying the host cell to reduce flux through the citric acid cycle (TCA). In other embodiments, the yield and productivity are uncoupled by reducing the levels of ATP in the host cell.

Find Patent Forward Citations

Chua, Penelope. (2024). Methods for decoupling yield and productivity of a non-catabolic compound produced by a host cell (U.S. Patent No. 12098407). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12098407

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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