The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2024

Filed:

Jun. 21, 2022
Applicant:

Keio University, Tokyo, JP;

Inventor:

Minoru Ko, Tokyo, JP;

Assignee:

KEIO UNIVERSITY, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/077 (2010.01); C12N 5/0793 (2010.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0658 (2013.01); C12N 5/0619 (2013.01); C12N 5/067 (2013.01); C12N 15/09 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2506/02 (2013.01);
Abstract

In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.


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