The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Mar. 12, 2021
University of Massachusetts, Boston, MA (US);
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
Thoru Pederson, Worcester, MA (US);
Scot Andrew Wolfe, Winchester, MA (US);
Hanhui Ma, Shrewsbury, MA (US);
Metewo Selase Kosi Enuameh, Gaithersburg, MD (US);
Nicola Anne Kearns, Somerville, MA (US);
Ryan Michael Jude Genga, Framingham, MA (US);
Rene Maehr, Newton, MA (US);
Shaojie Zhang, Oviedo, FL (US);
Ardalan Naseri, Orlando, FL (US);
Manuel Garber, Winchester, MA (US);
University of Massachusetts, Boston, MA (US);
Abstract
The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal CRISPR/Cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state.