The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Aug. 03, 2020
Emulate, Inc., Boston, MA (US);
Janna Nawroth, Boston, MA (US);
Riccardo Barrile, Boston, MA (US);
David Conegliano, Boston, MA (US);
Remi Villenave, Boston, MA (US);
Carolina Lucchesi, Westwood, MA (US);
Justin Nguyen, Medford, MA (US);
Antonio Varone, West Roxbury, MA (US);
Catherine Karalis, Brookline, MA (US);
Geraldine Hamilton, Boston, MA (US);
EMULATE, INC., Boston, MA (US);
Abstract
An in vitro microfluidic 'organ-on-chip' device is described herein that mimics the structure and at least one function of specific areas of the epithelial system in vivo. In particular, a stem cell-based Lung-on-Chip is described. This in vitro microfluidic system can be used for modeling differentiation of cells on-chip into lung cells, e.g., a lung (Lung-On-Chip), bronchial (Airway-On-Chip; small-Airway-On-Chip), alveolar sac (Alveolar-On-Chip), etc., for use in modeling disease states of derived tissue, i.e. as healthy, pre-disease and diseased tissues. Additionally, stem cells under differentiation protocols for deriving (producing) differentiated lung cells off-chips may be seeded onto microfluidic devices at any desired point during the in vitro differentiation pathway for further differentiation on-chip or placed on-chip before, during or after terminal differentiation.