The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Oct. 18, 2019
Mogam Institute for Biomedical Research, Yongin-si, KR;
Ki Joon Cho, Yongin-si, KR;
Mijung Lee, Yongin-si, KR;
Eun Jung Song, Yongin-si, KR;
Ki Su Kim, Yongin-si, KR;
Kwan Yub Kang, Yongin-si, KR;
Eui Cheol Cho, Yongin-si, KR;
MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH, Yongin-si, KR;
Abstract
An asymmetric fusion protein in which a fragment of an antibody binding to an insulin receptor, an iduronate-2-sulfatase (IDS) enzyme, and an Fc region are fused, and a use thereof are disclosed. The fusion protein can cross the blood-brain barrier (BBB) to deliver the IDS enzyme to the brain. Therefore, a pharmaceutical composition containing the fusion protein as an active ingredient can be used as a therapeutic agent for a central nervous system disease and particularly, is expected to prevent and treat various diseases caused by ribosome accumulation.