The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Oct. 10, 2017
Applicant:
The National Institute for Biotechnology IN the Negev Ltd., Beer Sheva, IL;
Inventors:
Assignee:
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer Sheva, IL;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 35/15 (2015.01); A61K 35/17 (2015.01); A61K 48/00 (2006.01); A61P 3/00 (2006.01); A61P 9/00 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/18 (2006.01); C12N 5/0783 (2010.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); A61K 48/00 (2013.01); A61P 3/00 (2018.01); A61P 9/00 (2018.01); A61P 25/28 (2018.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70532 (2013.01); C07K 16/18 (2013.01); C07K 16/2818 (2013.01); C12N 5/0636 (2013.01); C12N 5/0638 (2013.01); C12N 5/0646 (2013.01); C07K 2317/74 (2013.01); C07K 2317/75 (2013.01); C07K 2319/03 (2013.01); C07K 2319/41 (2013.01); C07K 2319/60 (2013.01); C12N 2501/25 (2013.01); C12N 2501/335 (2013.01); C12N 2501/515 (2013.01); C12N 2502/30 (2013.01); C12N 2510/00 (2013.01);
Abstract
Modified cells comprising a transmembrane polypeptide comprising at least one extracellular target receptor-binding domain, a transmembrane domain and an intracellular domain, wherein the intracellular domain is not capable of transducing any signal are provided. Methods of inducing or inhibiting signaling by a target receptor in a target cell comprising contacting the target cell with a modified cell of the invention are also provided.