The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2024

Filed:

Oct. 12, 2022
Applicant:

National Technology & Engineering Solutions of Sandia, Llc, Albuquerque, NM (US);

Inventors:

Brooke Nicole Harmon, Livermore, CA (US);

Maxwell Stefan, Pleasanton, CA (US);

Jennifer Schwedler, Livermore, CA (US);

Christopher Sumner, Livermore, CA (US);

Yooli Kim Light, Pleasanton, CA (US);

Catherine Margaret Mageeney, Livermore, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 31/14 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61P 31/14 (2018.01); C12N 15/63 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01);
Abstract

Provided herein are single domain antibodies (sdAbs) configured for passing the blood brain barrier in a human or mammal brain. Methods of using such sdAbs are also described herein, such as methods of binding to brain cells, binding with and transporting other sdAbs with beneficial functionalities, binding to and transporting biochemical or pharmaceutical species with beneficial functionalities, and treating, diagnosing, or prophylactically treating a disease, malignancy, or condition.


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