The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Dec. 15, 2020
Self-assembled nanoparticle containing gb protein of eb virus and preparation method and use thereof
Sun Yat-sen University, Guangdong, CN;
Sun Yat-sen University Cancer Center (Sysucc), Guangdong, CN;
Musheng Zeng, Guangdong, CN;
Cong Sun, Guangdong, CN;
Yixin Zeng, Guangdong, CN;
Guokai Feng, Guangdong, CN;
Yinfeng Kang, Guangdong, CN;
Xinchun Chen, Guangdong, CN;
Xiao Zhang, Guangdong, CN;
Qianying Zhu, Guangdong, CN;
Jiangping Li, Guangdong, CN;
Xiangwei Kong, Guangdong, CN;
SUN YAT-SEN UNIVERSITY, Guangdong, CN;
SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC), Guangdong, CN;
Abstract
The present invention is related to a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.