logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12098117 B1

PDFFull Text
Date of Patent:
Sep. 24, 2024

Filed:

Dec. 11, 2019

Compositions and methods for the treatment of cancer

Applicant:

Duke University, Durham, NC (US);

Inventors:

Dennis J. Thiele, Chapel Hill, NC (US);

Bushu Dong, Durham, NC (US);

Alexander M. Jaeger, Cambridge, MA (US);

Philip F. Hughes, Chapel Hill, NC (US);

Timothy Haystead, Durham, NC (US);

Jiyong Hong, Durham, NC (US);

Assignee:

Duke University, Durham, NC (US);

Attorney:

POLSINELLI PC

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Kyle Nottingham

Int. Cl.
CPC ...
C07C 275/30 (2006.01); A61P 35/00 (2006.01); C07C 211/40 (2006.01); C07C 255/60 (2006.01); C07C 275/28 (2006.01); C07C 275/34 (2006.01); C07C 275/40 (2006.01); C07C 275/42 (2006.01); C07C 279/18 (2006.01); C07C 279/28 (2006.01); C07C 281/06 (2006.01); C07C 311/46 (2006.01); C07C 317/36 (2006.01); C07C 317/42 (2006.01); C07D 213/40 (2006.01); C07D 213/75 (2006.01); C07D 223/04 (2006.01); C07D 229/02 (2006.01); C07D 231/56 (2006.01); C07D 233/64 (2006.01); C07D 241/24 (2006.01); C07D 249/14 (2006.01); C07D 271/12 (2006.01); C07D 285/10 (2006.01); C07D 317/66 (2006.01); C07D 333/20 (2006.01); C07D 333/36 (2006.01); C07D 333/72 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07C 275/30 (2013.01); A61P 35/00 (2018.01); C07C 211/40 (2013.01); C07C 255/60 (2013.01); C07C 275/28 (2013.01); C07C 275/34 (2013.01); C07C 275/40 (2013.01); C07C 275/42 (2013.01); C07C 279/18 (2013.01); C07C 279/28 (2013.01); C07C 281/06 (2013.01); C07C 311/46 (2013.01); C07C 317/36 (2013.01); C07C 317/42 (2013.01); C07D 213/40 (2013.01); C07D 213/75 (2013.01); C07D 223/04 (2013.01); C07D 229/02 (2013.01); C07D 231/56 (2013.01); C07D 233/64 (2013.01); C07D 241/24 (2013.01); C07D 249/14 (2013.01); C07D 271/12 (2013.01); C07D 285/10 (2013.01); C07D 317/66 (2013.01); C07D 333/20 (2013.01); C07D 333/36 (2013.01); C07D 333/72 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 417/12 (2013.01);
Abstract

This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.

Find Patent Forward Citations

Loading…