The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Apr. 17, 2020
Rutgers, the State University of New Jersey, New Brunswick, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Pengfei Xie, Piscataway, NJ (US);
Mehdi Javanmard, West Windsor, NJ (US);
Mark George Allen, Philadelphia, PA (US);
Wen Shen, Arlington, TX (US);
Naixin Song, Philadelphia, PA (US);
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.