The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Oct. 27, 2011
Vikas Kundra, Missouri City, TX (US);
James A. Bankson, Pearland, TX (US);
Ananth Annapragada, Manvel, TX (US);
Ketan B. Ghaghada, Houston, TX (US);
Murali K. Ravoori, Pearland, TX (US);
Vikas Kundra, Missouri City, TX (US);
James A. Bankson, Pearland, TX (US);
Ananth Annapragada, Manvel, TX (US);
Ketan B. Ghaghada, Houston, TX (US);
Murali K. Ravoori, Pearland, TX (US);
Abstract
Provided herein are nanoparticle-based gadolinium (Gd) agents which may be used, e.g., in T1-weighted MR imaging (MRI). In various embodiments, dual-Gd liposomal agents are provided which contain both core-encapsulated Gd as well as surface-conjugated Gd. In various embodiments, these agents were observed to deliver a higher concentrations of Gd and result in substantial improvements in signal to noise ratios and contrast to noise ratios. Also provided are methods for in vivo imaging and/or treating diseases such as cancer or tumor in a subject.