The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2024

Filed:

Apr. 12, 2021
Applicants:

University of Central Florida Research Foundation, Inc., Orlando, FL (US);

Sanford Burnham Prebys Medical Discovery Institute AT Lake Nona, Orlando, FL (US);

Memorial Sloan Kettering Cancer Center, New York, NY (US);

Inventors:

Annette Khaled, Orlando, FL (US);

Jesus Manuel Perez Figueroa, Los Angeles, CA (US);

Santimukul Santra, Pittsburg, KS (US);

Charalambos Kaittanis, Cambridge, MA (US);

Oscar Santiesteban, El Segundo, CA (US);

Jan Grimm, Larchmont, NY (US);

Hampton Sessions, Orlando, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); A61K 51/10 (2006.01); A61K 51/12 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6869 (2017.08); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 45/06 (2013.01); A61K 47/6935 (2017.08); A61K 51/1072 (2013.01); A61K 51/1244 (2013.01);
Abstract

Provided herein is a nanoparticle for drug delivery, wherein the nanoparticle comprises a hyperbranched polyester (HBPE) nanoparticle having a hydrophobic interior, polyglutamate folate ligands conjugated to the nanoparticle, and one or more PET detectable isotopes. Also provided herein are methods of using thereof.


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