The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2024
Filed:
Jul. 29, 2021
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Alexander O. Mujica, Elmsford, NY (US);
Elena Burova, Mount Kisco, NY (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Assignee:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/0278 (2024.01); A01K 67/0276 (2024.01); A61K 49/00 (2006.01); C07K 14/705 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A01K 67/0276 (2013.01); A61K 49/0008 (2013.01); C07K 14/70503 (2013.01); A01K 2207/15 (2013.01); A01K 2217/072 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A01K 2267/01 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0331 (2013.01); C07H 21/04 (2013.01); C12N 15/63 (2013.01); C12N 15/79 (2013.01); C12N 2510/00 (2013.01); C12N 2517/02 (2013.01);
Abstract
Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Lymphocyte activation gene 3 (Lag3). The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Lag3 locus so that the non-human animals express a Lag3 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).