The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2024
Filed:
May. 08, 2020
Applicant:
Sartorius Stedim Biotech Gmbh, Göttingen, DE;
Inventors:
Assignee:
Sartorius Stedim Biotech GmbH, Gottingen, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 30/86 (2006.01); G01N 30/88 (2006.01); G16B 40/10 (2019.01); C07K 1/16 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 30/8658 (2013.01); G01N 30/88 (2013.01); G16B 40/10 (2019.02); C07K 1/16 (2013.01); G01N 2030/027 (2013.01); G01N 2030/8831 (2013.01);
Abstract
The present invention relates to a method of determining the concentration of at least one compound in a chromatography method, wherein fluctuations of the stationary phase's spatial structure due to variations of the composition of the mobile phase and/or the chromatography temperature are considered by calculating the concentration c(z, t) based on the flow velocity ν and the bulk porosity ε, which may vary due to the varying composition and/or temperature and which are determined for the varying composition of the mobile phase and/or the varying chromatography temperature.