The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 17, 2024

Filed:

Sep. 23, 2020
Applicant:

Twist Bioscience Corporation, South San Francisco, CA (US);

Inventors:

Ray Tabibiazar, Chattanooga, TN (US);

Aaron Sato, Burlingame, CA (US);

Pankaj Garg, Burlingame, CA (US);

Qiang Liu, Palo Alto, CA (US);

Assignee:

Twist Bioscience Corporation, South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); C07K 16/28 (2006.01); C12N 15/10 (2006.01); C40B 40/08 (2006.01);
U.S. Cl.
CPC ...
C40B 40/10 (2013.01); C07K 16/2896 (2013.01); C12N 15/1044 (2013.01); C40B 40/08 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01);
Abstract

Provided herein are methods and compositions relating to prostaglandin D2 receptor 2 (DP2 or CRTH2R) libraries having nucleic acids encoding for a scaffold comprising a CRTH2R binding domain. CRTH2R libraries described herein encode for immunoglobulins including antibodies and single domain antibodies. Libraries described herein include variegated libraries comprising nucleic acids each encoding for a predetermined variant of at least one predetermined reference nucleic acid sequence. Further described herein are protein libraries generated when the nucleic acid libraries are translated. Further described herein are cell libraries expressing variegated nucleic acid libraries described herein.


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