The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2024
Filed:
Mar. 16, 2021
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Sudipta Seal, Orlando, FL (US);
Soumen Das, Orlando, FL (US);
William Self, Oviedo, FL (US);
Dwight Towler, La Jolla, CA (US);
University of Central Florida Research Foundation, Inc., Orlando, FL (US);
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Abstract
An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coating. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.