The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2024
Filed:
Sep. 26, 2023
Applicant:
University of Florida Research Foundation, Inc., Gainesville, FL (US);
Inventors:
Daiqing Liao, Gainsville, FL (US);
Iqbal Mahmud, Gainesville, FL (US);
Guimei Tian, Hawthorne, FL (US);
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/04 (2006.01); A61K 47/10 (2017.01); A61K 47/36 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/04 (2013.01); A61K 47/10 (2013.01); A61K 47/36 (2013.01); A61P 35/00 (2018.01); A61K 45/06 (2013.01);
Abstract
Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.