The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
Mar. 30, 2021
Ventana Medical Systems, Inc., Tucson, AZ (US);
Johns Hopkins University, Baltimore, MD (US);
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Mehrnoush Khojasteh, Tucson, AZ (US);
Jim F. Martin, Tucson, AZ (US);
Lidija Pestic-Dragovich, Tucson, AZ (US);
Lei Tang, Tucson, AZ (US);
Xiangxue Wang, Tucson, AZ (US);
Wenjun Zhang, Tucson, AZ (US);
Robert Anders, Baltimore, MD (US);
Luis Diaz, New York, NY (US);
Ventana Medical Systems, Inc.;
Memorial Sloan Kettering Cancer Center, New York, NY (US);
Abstract
A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.