The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
Jul. 23, 2021
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Congwei Wang, Basel, CH;
Christian Weile, Farum, DK;
Martin Ebeling, Grenzach-Wyhlen, DE;
Lars Joenson, Viby Sjaelland, DK;
Jonas Vikesaa, Fredensborg, DK;
Ravi Jagasia, Basel, CH;
Meiling Li, Aargau, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); C12N 2310/11 (2013.01); C12N 2310/3231 (2013.01);
Abstract
The present invention relates to antisense oligonucleotides which are complementary to conserved TDP-43 binding sites on pre-mRNA transcripts, which are capable of restoring RNA binding protein function in the processing of multiple independent mRNAs in TDP-43 depleted cells.