The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
Nov. 08, 2022
Applicants:
Technion Research & Development Foundation Limited, Haifa, IL;
The University of Tokyo, Tokyo, JP;
Inventors:
Ashraf Brik, Haifa, IL;
Mickal Nawatha, Reine, IL;
Hiroaki Suga, Tokyo, JP;
Joseph Rogers, Tokyo, JP;
Assignees:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, Haifa, IL;
THE UNIVERSITY OF TOKYO, Tokyo, JP;
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/64 (2006.01); A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/64 (2013.01); A61P 35/00 (2018.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention is directed to a cyclic polypeptide having ubiquitin binding affinity (K) of 0.1-100 nM. Further provided are methods for reducing deubiquitination activity of a cell, and for treating cancer in a subject in need thereof.