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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12084472 B1

PDFFull Text
Date of Patent:
Sep. 10, 2024

Filed:

Feb. 25, 2021

Substituted 4-phenyl pyridine compounds as non-systemic tgr5 agonists

Applicant:

Ardelyx, Inc., Fremont, CA (US);

Inventors:

Jason G. Lewis, Fremont, CA (US);

Michael Robert Leadbetter, Fremont, CA (US);

Jeremy Caldwell, Fremont, CA (US);

Dean Dragoli, Fremont, CA (US);

Noah Bell, Fremont, CA (US);

Jeffrey W. Jacobs, Fremont, CA (US);

Patricia Finn, Fremont, CA (US);

Rakesh Jain, Fremont, CA (US);

Tao Chen, Fremont, CA (US);

Matthew Siegel, Fremont, CA (US);

Assignee:

Ardelyx, Inc., Fremont, CA (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Sikarl A Witherspoon

Int. Cl.
CPC ...
A61K 31/444 (2006.01); A61K 31/4418 (2006.01); A61K 31/4425 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01); A61K 31/706 (2006.01); A61K 45/06 (2006.01); C07B 59/00 (2006.01); C07C 409/12 (2006.01); C07D 213/30 (2006.01); C07D 213/38 (2006.01); C07D 213/80 (2006.01); C07D 213/81 (2006.01); C07D 401/12 (2006.01); C07D 405/04 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 471/04 (2006.01); C07D 487/08 (2006.01); C07H 15/04 (2006.01); C07H 15/18 (2006.01); C07H 15/234 (2006.01); C07H 15/26 (2006.01);
U.S. Cl.
CPC ...
C07H 15/26 (2013.01); A61K 31/4418 (2013.01); A61K 31/4425 (2013.01); A61K 31/4427 (2013.01); A61K 31/443 (2013.01); A61K 31/4433 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); A61K 31/706 (2013.01); A61K 45/06 (2013.01); C07B 59/002 (2013.01); C07C 409/12 (2013.01); C07D 213/30 (2013.01); C07D 213/38 (2013.01); C07D 213/80 (2013.01); C07D 213/81 (2013.01); C07D 401/12 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 471/04 (2013.01); C07D 487/08 (2013.01); C07H 15/04 (2013.01); C07H 15/18 (2013.01); C07H 15/234 (2013.01); C07B 2200/05 (2013.01);
Abstract

The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula:

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