The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 2024

Filed:

Feb. 23, 2023
Applicant:

The Board of Regents of the University of Texas System, Austin, TX (US);

Inventors:

Kyoji Tsuchikama, Houston, TX (US);

Yasuaki Anami, Houston, TX (US);

Chisato Tsuchikama, Houston, TX (US);

Ningyang Zhang, Houston, TX (US);

Zhiqiang An, Houston, TX (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 247/04 (2006.01); A61K 31/40 (2006.01); A61K 45/06 (2006.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07D 209/20 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07C 247/04 (2013.01); A61K 31/40 (2013.01); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07D 209/20 (2013.01); C07D 403/12 (2013.01); A61K 45/06 (2013.01);
Abstract

In one aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.


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