The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2024
Filed:
Jul. 05, 2023
Applicant:
3-d Matrix, Ltd., Cambridge, MA (US);
Inventors:
Marika G. Rioult, Cambridge, MA (US);
Eun Seok Gil, Acton, MA (US);
Elton Aleksi, West Roxbury, MA (US);
Naoki Yamamoto, Hokuto, JP;
Assignee:
3-D Matrix, Ltd., Tokyo, JP;
Primary Examiner:
Int. Cl.
CPC ...
A61L 2/08 (2006.01); A61L 2/00 (2006.01); A61L 2/26 (2006.01); A61L 27/22 (2006.01); C07K 7/08 (2006.01); C12N 5/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/227 (2013.01); A61L 2/0035 (2013.01); A61L 2/081 (2013.01); A61L 2/26 (2013.01); C07K 7/08 (2013.01); C12N 5/0068 (2013.01); A61K 38/00 (2013.01);
Abstract
Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.