The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Mar. 09, 2020
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Anastasia Khvorova, Westborough, MA (US);
Mehran Nikan, Boston, MA (US);
Matthew Hassler, Worcester, MA (US);
Maire Osborn, Boston, MA (US);
Reka Haraszti, Boston, MA (US);
Andrew Coles, Boston, MA (US);
Anton Turanov, Boston, MA (US);
Neil Aronin, Newtonville, MA (US);
Assignee:
UNIVERSITY OF MASSACHUSETTS, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 47/54 (2017.01); A61K 47/61 (2017.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); A61K 47/542 (2017.08); A61K 47/554 (2017.08); A61K 47/61 (2017.08); C07H 21/00 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01);
Abstract
Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.