The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Aug. 08, 2018
Beijing Sig Biopharmaceutical Technology Co., Ltd., Beijing, CN;
Xiaoyan Qiu, Beijing, CN;
Jingshu Tang, Beijing, CN;
Zhi Yang, Beijing, CN;
Chong Wang, Beijing, CN;
Jingxuan Zhang, Beijing, CN;
Hua Zhu, Beijing, CN;
Zihan Geng, Beijing, CN;
Yang Liu, Beijing, CN;
Wenhua Jiang, Beijing, CN;
Jing Huang, Beijing, CN;
Beijing SIG Biopharmaceutical Technology Co., Ltd., Beijing, CN;
Abstract
IgG epitope and applications thereof as a target are provided. The IgG epitope is the C1 domain of non-B cell-derived IgG, and there is N-glycosylated sialic acid modification at the Asn162 site of the domain. The realization of its antigen functions must depend on the sialylation of the site. The present invention further discloses the applications of the IgG epitope as a drug target in preparing drugs for diagnosis and/or treatment of epithelial tumors. In addition, our studies showed that this antigen depends on the sialylation of Asn162 site as a drug target, and the sialylation of this site must depend on sialyltransferase ST3GAL4, indicating that the enzyme can be used as a drug target for preparing tumor therapeutic drugs. Further, integrin β4 is co-expressed and co-localized with IgG containing the epitope. IgG can be used as a marker for preparing drugs for the auxiliary detection of epithelial tumors.