The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
May. 06, 2019
Applicants:
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Jerusalem, IL;
Nectin Therapeutics Ltd., Jerusalem, IL;
Inventors:
Ofer Mandelboim, Shoham, IL;
Adi Reches, Koranit, IL;
Stipan Jonjic, Rijeka, HR;
Pinchas Tsukerman, Jerusalem, IL;
Assignees:
NECTIN THERAPEUTICS LTD., Jerusalem, IL;
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW, Jerusalem, IL;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2803 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 2039/505 (2013.01);
Abstract
The present invention provides monoclonal antibodies that recognize human Nectin4 with high affinity and specificity and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy and in diagnosis.