The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
May. 30, 2019
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Hidetomo Kitamura, Gotemba, JP;
Maiko Hoshino, Singapore, SG;
Yang Sun, Singapore, SG;
Taichi Kuramochi, Singapore, SG;
Wenjie Tu, Gotemba, JP;
Tomoyuki Igawa, Singapore, SG;
Naoka Hironiwa, Singapore, SG;
Yuki Noguchi, Gotemba, JP;
Chugai Seiyaku Kabushiki Kaisha, Tokyo, JP;
Abstract
The present invention provides a polypeptide comprising an antigen binding domain which binds to an antigen present in cartilage tissue, and also provides use of the polypeptide. The polypeptide of the invention is useful for penetrating and/or retaining a desired substance in the cartilage tissue for a long period. The present invention further relates to a polypeptide comprising (i) an antigen binding domain which binds to a molecule in a cartilage tissue, and (ii) a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, and a pharmaceutical composition comprising the polypeptide. The present invention further relates to methods for producing and screening for the polypeptide.