The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Jan. 25, 2023
Astex Therapeutics Limited, Cambridge, GB;
Cancer Research Technology Limited, London, GB;
Steven Howard, Cambridge, GB;
Benjamin David Cons, Cambridge, GB;
Jeffrey David St. Denis, Cambridge, GB;
Rhian Sara Holvey, Cambridge, GB;
Guillaume François Parra, Ste. Eulalie, FR;
Kim Louise Hirst, Saffron Walden, GB;
Isabelle Anne Lemasson, Cambridge, GB;
David John Nash, Saffron Walden, GB;
James Daniel Osborne, Cambridge, GB;
Jonas Calleja Priede, Cambridge, GB;
Nicholas Paul Richards, Haverhill, GB;
Aaron Michael Dumas, Stevenage, GB;
Brian Christopher Bishop, Harlow, GB;
David Parry-Jones, Welwyn Garden, GB;
Meenakshi Sundaram Shanmugham, London, GB;
Darren James Dixon, Oxford, GB;
Matthew James Gaunt, Cambridge, GB;
ASTEX THERAPEUTICS LIMITED, Cambridge, GB;
CANCER RESEARCH TECHNOLOGY LIMITED, London, GB;
Abstract
The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.