The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Dec. 05, 2019
Applicant:
Intellia Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Stephen S. Scully, Cambridge, MA (US);
Micah Maetani, Cambridge, MA (US);
Ramsey Majzoub, Cambridge, MA (US);
Assignee:
Intellia Therapeutics, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07C 219/04 (2006.01); A61P 1/16 (2006.01); C07C 271/20 (2006.01); C07D 205/04 (2006.01); C07D 207/09 (2006.01); C07D 211/46 (2006.01); C07D 211/62 (2006.01); C07D 271/10 (2006.01); C07D 295/08 (2006.01); C12N 15/113 (2010.01); B82Y 5/00 (2011.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01);
U.S. Cl.
CPC ...
C07C 219/04 (2013.01); A61P 1/16 (2018.01); C07C 271/20 (2013.01); C07D 205/04 (2013.01); C07D 207/09 (2013.01); C07D 211/46 (2013.01); C07D 211/62 (2013.01); C07D 271/10 (2013.01); C07D 295/08 (2013.01); C12N 15/113 (2013.01); B82Y 5/00 (2013.01); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01);
Abstract
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.