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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12076437 B1

PDFFull Text
Date of Patent:
Sep. 03, 2024

Filed:

Jul. 12, 2022

Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue

Applicant:

Brown University, Providence, RI (US);

Inventors:

Kareen L. K. Coulombe, Pawtucket, RI (US);

Stephanie Roser, Florham Park, NJ (US);

Fabiola Munarin, Smithfield, RI (US);

Alicia Minor, Providence, RI (US);

Assignee:

BROWN UNIVERSITY, Providence, RI (US);

Attorney:

Adler Pollock & Sheehan P.C.

Primary Examiner:

Andrew D Kosar

Assistant Examiner:

John D McAnany

Int. Cl.
CPC ...
A61K 9/06 (2006.01); A61K 38/18 (2006.01); A61K 38/30 (2006.01); A61K 47/36 (2006.01); A61K 47/42 (2017.01);
U.S. Cl.
CPC ...
A61K 9/06 (2013.01); A61K 38/1825 (2013.01); A61K 38/1858 (2013.01); A61K 38/1866 (2013.01); A61K 38/30 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01);
Abstract

The invention provides a highly versatile system to promote vascularization in ischemic tissue. The system is composed of a fully defined, customizable hydrogel loaded with a potent cocktail of proangiogenic growth factors. The hydrogel's mechanical, degradation, and factor release behavior can be tailored to the specifications of any given target tissue or ischemic disease state. The growth factor cocktail can be optimized for maximal vessel density or size to meet the perfusion specifications required by the tissue. The embodiments of the disclosure concern methods and compositions of the system, with examples of preparation for both injectable and implantable delivery modes.

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Coulombe, Kareen L. K.. (2024). Proangiogenic protein cocktails delivered in custom biomaterials to revascularize ischemic tissue (U.S. Patent No. 12076437). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12076437

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