The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2024
Filed:
Mar. 23, 2023
Araris Biotech Ag, Au, CH;
Philipp Spycher, Au, CH;
Philipp Probst, Au, CH;
Isabella Attinger-Toller, Au, CH;
Romain Bertrand, Au, CH;
Ramona Stark, Au, CH;
Dragan Grabulovski, Au, CH;
ARARIS BIOTECH AG, Au, CH;
Abstract
The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker comprising the structure (shown in N→C direction) (Sp)-RK-(Sp)-B-(Sp) or (Sp)-B-(Sp)-RK-(Sp) to a Gln residue comprised in an antibody, wherein (Sp) is a chemical spacer or is absent; (Sp) is a chemical spacer or is absent; (Sp) is a chemical spacer or is absent; R is arginine or an arginine derivative or an arginine mimetic; K is lysine or a lysine derivative or a lysine mimetic; B is a linking moiety or a payload; and wherein the linker is conjugated to the Gin residue comprised in the antibody via a primary amine comprised in the side chain of the lysine residue, the lysine derivative or the lysine mimetic. Further, the invention relates to antibody-linker conjugates, antibody-drug conjugates and linker constructs comprising an RK motif.